Unfortunately, if you lose your job before your loan closes, your application could be denied automatically. If you’re married, and your wife makes enough money to cover the loan payments, it’s possible the lender will approve your loan anyway. If you lose your job, don’t give up hope. Wait until the situation changes and you find work. I suggest you look for the same line of work, earning the same or more than before, to avoid being subjected to this two-year (employment) rule when you reapply for the loan.